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The TSHR structure was obtained from input from
- X-ray structure for the Leucine-Rich Domain (LRD)
- Homology model for the Trans-Memerane domain *TMD) helices
- Monte Carlo generated loops connectig the helices
- Alphafold and CyoEM provided input for thei Linking Region (LR)
- Grand-canonical ensemble Monte Carlo generated waters in the TMD
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