Use of circular variance to quantify the deviation of a macromolecule from the spherical shape Abstract: It is shown that the extent of deviation of a molecular shape from spherical can be characterized by comparing the distribution of the circular variances, a measure originally proposed to quantify angular spread, of the vectors from each atom to the rest of the molecule to the circular variance of a collection of atoms filling the unit sphere. Different measures for quantifying the difference between distributions are proposed and compared.